Cell membranes of mammalian tissues contain several types of glucose transporters. Glucose transporters regulate the level of intracellular glucose playing an important role in cell energy function.
The modification of glucose transport activity causes several physiological effects. One such effect is decrease in glucose level. Only a few compounds have been known to affect glucose transport activity. Therefore, finding an activator of glucose transport is more beneficial. Forskolin, a known glucose transport inhibitor, is useful as a control for in vitro tests of glucose uptake.
Simple experimental models are especially valuable in testing nutritional supplements and herbal extracts. Ehrlich ascites tumor cells are useful for measuring glucose transport activity. They are known to contain a glucose transporter and are easily propagated, making them useful as a simple experimental system for screening this important function. When the time course of 2-deoxy-D-glucose (2-DG) uptake by Ehrlich cells
was measured, the rate of uptake was determined to be linear for up to 2 minutes at concentrations of 0.2 to 1.0 µM. Forskolin was determined to be useful as a control.
Corosolic acid, the active ingredient in Glucos-BalanceTM, showed a significant glucose transport-stimulating, at a concentration of 1 µM. A recent report indicates that oral administration of Corosolic acid in normo-glycemic rats resulted in a hypoglycemic effect. This result correlates with glucose uptake indicated by the above in vitro assay.
Glucos-Balance is the herbal answer for weight loss and blood glucose maintenance.